MAGEC2 (EP405), RMab

Summary and Explanation

MAGEC2 is used to distinguish Seminomas from Embryonal Carcinomas. MAGEC2 marker is a tool for the differential diagnosis of testicular germ cell tumors. Immunohistochemical expression of MAGEC2 has a consistent and strong nuclear signal in 100% of non-neoplastic germ cells and Intratubular Germ Cell Neoplasia of Unclassified type (IGCNU). The staining is very strong in immature forms of spermatogonia and spermatocytes, but weakens gradually with more mature forms like spermatids. No MAGEC2 expression was found in normal mature sperm cells. In Seminomas, MAGEC2 is expressed in 238 of 254 cases. From the other germ cell tumor components: 5 of 51 yolk sac tumors (10%) and 1 of 10 choriocarcinomas (10%) were positive, but none of the Embryonal Carcinomas or Teratomas had any nuclear expression of MAGEC2 marker. MAGEC2 can be identified as a sensitive marker to differentiate Seminomas from other types of Germ Cell tumors.