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MNDA, anti-mnda, Myeloid cell Nuclear Differentiation Antigen, anti-Myeloid cell Nuclear Differentiation Antigen MAIN

MNDA (BSB-157), MMab

Presentation:

Price: $202.00

SKU:	BSB-3738-3
Antibody type:	Mouse Monoclonal
Clone:	BSB-157
Isotype:	IgG1
Concentrate Dilution:	1:50-1:200
Localization:	Nuclear
Tissue Control:	Breast, Colon, Falopian Tube, Brain
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Myeloid cell Nuclear Differentiation Antigen (MNDA) is present in granulocytes and monocytes (myeloid and B cells), found in the marginal zones of germinal centers in tonsil, lymph node, spleen. MNDA is a highly basic protein from 1q22, and is part of the family of nuclear proteins expressed in reaction to interferons. MNDA contains a Pyrin ‘death domain’ used in self-association and is suggested to induce or help prevent different programmed cell death pathways in hematopoietic cells.

MNDA antibody expression is studied mainly in leukemias and lymphomas. MNDA antibody is a marker to distinguish Nodal Marginal Zone Lymphoma from Follicular Lymphoma, and has been shown to be downregulated in Myelodysplastic Syndrome, a precursor for Leukemia. MNDA overexpression in Osteosarcoma induces apoptosis and protects patients from metastasis, and expression in Chronic Lymphocytic Leukemia indicates the degradation of anti-apoptotic mRNA, allowing cells suffering genotoxic stress to undergo apoptosis.

Synonyms: MNDA, anti-mnda, Myeloid cell Nuclear Differentiation Antigen, anti-Myeloid cell Nuclear Differentiation Antigen

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3738-3	$202.00
Presentation: 7 ml Predilute	BSB-3738-7	$363.00
Presentation: 15 ml Predilute	BSB-3738-15	$639.00
Presentation: .1 ml Concentrate	BSB-3738-01	$211.00
Presentation: .5 ml Concentrate	BSB-3738-05	$458.00
Presentation: 1 ml Concentrate	BSB-3738-1	$727.00
Presentation: Control Slides [5]	BSB-3738-CS	$77.05

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MNDA (BSB-157), MMab

Intended Use

Summary and Explanation

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