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Melanosome HMB45 (HMB-45), MMab

Presentation:

Price: $180.60

SKU:	BSB 5757
Antibody type:	Mouse Monoclonal
Clone:	HMB-45
Isotype:	IgG1/K
Concentrate Dilution:	1:250-1:1000
Localization:	Cytoplasmic
Tissue Control:	Melanoma
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Melanosome / HMB-45 antibody reacts against an antigen present in immature melanosomes, cutaneous melanocytes, prenatal and infantile retinal pigment epithelium cells. This antibody was generated to an extract of Melanoma. It reacted positively against Melanocytic Tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, this antibody reacts positively against juntional nebus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes.

This antibody is very useful to identify Malignant Melanoma. Metastatic Amelanotic Melanoma can often be confused with a variety of poorly differentiated Carcinomas, Large Cell Lymphomas, Sarcomas, Spindle Cell Carcinomas and various types of mesenchymal neoplasms. A keratin-negative, vimentin-rich neoplasm that immunoreacts with antibody to S-100 protein and with this melanoma antibody, is, with rare exception, a Melanoma.

Presentation

Melanosome antibody (HMB-45) is a mouse monoclonal from tissue culture supernatant that is diluted in Phosphate Buffered Saline, pH 7.6, with protein base, and preserved with Sodium Azide preservative.

Synonyms: S 100 protein, S100, HMB 45, Melan A, Mitf, microphthalmia transcription factor, MART 1, human melanoma black 45, anti-hmb45, anti-hmb-45, anti-hmb 45, anti hmb45, anti hmb-45, anti hmb 45

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 5757	$180.60
Presentation: 7 ml Predilute	BSB 5758	$328.65
Presentation: 15 ml Predilute	BSB 5759	$547.05
Presentation: .1 ml Concentrate	BSB 5760	$136.50
Presentation: .5 ml Concentrate	BSB 5761	$313.95
Presentation: 1 ml Concentrate	BSB 5762	$459.90
Presentation: Control Slides [5]	BSB 5763	$67.00