NPM1 / B23 (BSB-124), MMab

Summary and Explanation

Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23, is a protein that in humans is encoded by the NPM1 gene. The nuclear protein B23 (also referred to as nucleophosmin) is involved in ribosomal assembly, rRNA transport, centrosome duplication, maintenance of genomic stability, and embryonic development.

NPM1 gene is up-regulated, mutated and chromosomally translocated in many tumor types. Chromosomal aberrations involving NPM1 were found in patients with non-Hodgkin lymphoma, Acute Promyelocytic Leukemia, Myelodysplastic Syndrome, and Acute Myelogenous Leukemia. NPM1 antibody is a nuclear protein. In approximately 50% to 60% of cytogenetically normal Acute Myeloid Leukemia (AML), NPM1 is mutated and localized in the cytoplasm. Both wild type and mutant NPM1 can be detected by immunohistochemistry (IHC). The expression of NPM1 is heterogeneous in gastric tumors. NPM1 down-regulation may have a role in gastric carcinogenesis and may help in the selection of anticancer treatment strategies. NPM1 has a critical role in the regulation of colon cancer cells migration and invasion and it may serve as a potential marker for the prognosis of colon cancer patients.