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PD-1 / CD279 (EP239), RMab
SKU: |
BSB 3148 |
Antibody type:
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Rabbit Monoclonal
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Clone:
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EP239
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Isotype:
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IgG
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Concentrate Dilution:
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1:50-1:200
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Localization:
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Cytoplasmic, Membranous
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Tissue Control:
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Tonsil, Lymph Node, Thymus, Spleen
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Programmed Death 1 (PD-1 or CD279) is a Type I membrane protein comprised of 268 amino acids. PD-1 is a member of the extended CD28/CTLA-4 family of T-cell regulators. PD-1 is expressed on the surface of activated T-cells, B-cells, and macrophages. In comparison to CTLA-4, PD-1 more broadly negatively regulates immune responses.
New data suggests that expression of PD-L1 on tumor cells inhibits anti-tumor activity through engagement of PD-1 on effector T-cells. Expression of PD-L1 on tumors is correlated with reduced survival in esophageal, pancreatic and other types of cancers, highlighting the relevance of exploring the PD-1 pathway as a target for immunotherapy. Studies have found that PD-1 antibody is expressed on most T-cells and a small subset of B-cells in the light zone of germinal centers, but not elsewhere in the tonsil. On that basis, it was postulated that PD-1 may play a role in the process of clonal selection of centrocytes, which occurs in this subanatomic site in germinal centers. PD-1 antibody is a new marker of Angioimmunoblastic Lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and bcl-6, PD-1 is expressed by few B-cells, so it may be a more specific and useful diagnostic marker in Angioimmunoblastic Lymphoma. It also seems to stain a greater percentage of CD3-positive neoplastic cells in Angioimmunoblastic Lymphoma than either CD10 or bcl-6.
Presentation
PD-1 antibody (CD279 antibody) is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: Pdcd1, Pdcd 1, pd-1, ant-pd1, anti-pd-1, ant-pd1, anti pd-1, Ly101, mPD 1, pd1, PD 1, Pdc1, programmed cell death 1, programmed cell death protein 1, protein PD 1, RMP114, RMP1 14
Specification Sheets
Safety Data Sheets
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 3148 | $272.00 |
Presentation: 7 ml Predilute | BSB 3149 | $410.00 |
Presentation: 15 ml Predilute | BSB 3150 | $683.00 |
Presentation: .1 ml Concentrate | BSB 3151 | $272.00 |
Presentation: .5 ml Concentrate | BSB 3152 | $548.00 |
Presentation: 1 ml Concentrate | BSB 3153 | $956.00 |
Presentation: Control Slides [5] | BSB 3154 | $77.05 |
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