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PD-L1 / CD274 (RBT-PDL1), RMab
SKU: |
BSB 2649 (ASR) |
Antibody type:
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Rabbit Monoclonal
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Clone:
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RBT-PDL1
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Isotype:
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IgG
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Concentrate Dilution:
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1:25-1:100
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Localization:
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Membranous
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Tissue Control:
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Tonsil, Placenta, Lymphoblastic Lymphoma
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Species Reactivity:
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Human
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Intended Use
Analyte Specific Reagent
Summary and Explanation
PD-L1 is a new rabbit monoclonal antibody for immunohistochemistry from Bio SB. Programmed death-ligand 1 (PD-L1) also known as CD274 or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other diseases. The upregulation of PD-L1 may allow cancers to evade the host immune system. An analysis of tumor specimens from patients with renal cell carcinoma found that high tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death. Ovarian cancer patients with higher expression of PD-L1 had a significantly poorer prognosis than those with lower expression. PD-L1 expression correlated inversely with intraepithelial CD8+ T-lymphocyte count, suggesting that PD-L1 on tumor cells may suppress antitumor CD8+ T cells. The PD-1/PD-L1 interaction is implicated in autoimmunity from several lines of evidence. In humans, PD-L1 was found to have altered expression in pediatric patients with Systemic lupus erythematosus. Studying isolated PBMC from healthy children, immature myeloid dendritic cells and monocytes expressed little PD-L1 at initial isolation, but spontaneously up-regulated PD-L1 by 24 hours. In contrast, both mDC and monocytes from patients with active SLE failed to upregulate PD-L1 over a 5 day time course, expressing this protein only during disease remissions.
Presentation
PD-L1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: PDL1, pd-l1, pdl-1, pd l1, pdl-1, pd -l1, pd- l1, pdl -1, pdl- 1, CD274, PDL-1, anti PDL1, anti-PDL1, anti-cd274, anti cd274, Pdcd1L1, Pdcd 1L1,CD274, CD274 molecule, B7 H, B7H1, PD L1, PDCD1LG1, PDL1
Specification Sheets
Safety Data Sheets
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 2649 (ASR) | $339.00 |
Presentation: 7 ml Predilute | BSB 2650 (ASR) | $618.00 |
Presentation: 15 ml Predilute | BSB 2651 (ASR) | $1,111.00 |
Presentation: .1 ml Concentrate | BSB 2652 (ASR) | $373.00 |
Presentation: .5 ml Concentrate | BSB 2653 (ASR) | $1,004.00 |
Presentation: 1 ml Concentrate | BSB 2654 (ASR) | $1,516.00 |
Presentation: Control Slides [5] | BSB-9339-CS | $77.00 |
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