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PDGFR-B (RBT-PDGFRB), RMab
| SKU: |
BSB 2349 |
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Antibody type:
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Rabbit Monoclonal
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Clone:
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RBT-PDGFRB
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Isotype:
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IgG
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Concentrate Dilution:
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1:10-1:50
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Localization:
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Cytoplasmic
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Tissue Control:
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Placenta, Breast, Kidney, Cervix
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Species Reactivity:
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Human, Mouse, Rat
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB.
The PDGFR-B antibody detects translocation of the PDGFR gene with the Tel gene, which is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Presentation
PDGFR-B antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: CD140B, PDGFR, PDGFRB, sc374573, PDGFR-β, PDGFR-beta, PDGFR-b, PDGFR b, PDGFR β, PDGFRβ, anti CD140B, anti PDGFR, anti PDGFR β, anti PDGFR-β, anti PDGFRB, anti PDGFRβ, anti-CD140B, anti-PDGFR, anti-PDGFR β, anti-PDGFR-β, anti-PDGFRB, anti-PDGFRβ, Beta platelet derived growth factor receptor, Beta type platelet derived growth factor receptor, CD140 antigen like family member B, JTK12, PDGF R beta, PDGFR 1, PDGFR beta, PDGFR1, platelet derived growth factor receptor 1, platelet derived growth factor receptor beta, platelet derived growth factor receptor beta polypeptide, pdgfrb, anti-pdgfrb, anti-pdgfr-b, anti pdgfr-b, anti pdgfrb
Specification Sheets
Safety Data Sheets
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| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2349 | $309.00 |
| Presentation: 7 ml Predilute | BSB 2350 | $563.00 |
| Presentation: 15 ml Predilute | BSB 2351 | $1,009.00 |
| Presentation: .1 ml Concentrate | BSB 2352 | $339.00 |
| Presentation: .5 ml Concentrate | BSB 2353 | $912.00 |
| Presentation: 1 ml Concentrate | BSB 2354 | $1,378.00 |
| Presentation: Control Slides [5] | BSB 2355 | $77.05 |
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