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pygopus 2, pygo2, anti-pygopus 2, pygopus-2, anti-pygo2, anti-pygo 2, pygo 2, anti pygo-2, pygo-2 MAIN

Pygopus 2 (BSB-156), MMab

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Price: $202.00

SKU:	BSB-3745-3
Antibody type:	Mouse Monoclonal
Clone:	BSB-156
Isotype:	IgG2a
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic. Membranous, Nuclear
Tissue Control:	Fallopian Tube, Adrenal Gland, Kidneys
Species Reactivity:	Human, Mouse, Rat

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Pygopus Family PHD Finger 2 (PYGO2) is a protein-coding gene associated with G-protein coupled receptor (GPCR) and Wnt signaling pathways, chromatin binding and histone acetyltransferase regulator activity. Pygo2 as a Wnt signaling pathway component has been detected in multiple cancer types.

One study found that abnormal Pygopus 2 antibody expression was associated with poor differentiation and a high tumor, node, and metastases stage and poor prognosis in non-small cell lung cancer (NSCLC) patients, therefore abnormal Pygo2 qntibody expression may be a marker for advanced NSCLC. Another study found that 59% of the patient tumor specimens exhibited positive Pygopus 2 antibody immunohistochemistry staining and increased intensity with the grade of malignancy, especially for WHO grade III and IV.

High-level expression has been reported in gliomas compared with normal brain tissues, which suggest an important role of Pygo2 in brain tumor progression. In a Colorectal Cancer study, the expression pattern of Pygo2 was evaluated by immunohistochemistry in tumor tissues and their normal margins, and found the expression of pygopus 2 antibody was detected in all tumor tissues. Furthermore, this expression was significantly higher in Colorectal Cancer samples than in normal tissues, and a significant association was found between Pygo2 protein expression in Colorectal Cancer and tumor cell metastasis to the lymph nodes. Pygo2 is also associated with Oligospermia

Synonyms: pygopus 2, pygo2, anti-pygopus 2, pygopus-2, anti-pygo2, anti-pygo 2, pygo 2, anti pygo-2, pygo-2

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3745-3	$202.00
Presentation: 7 ml Predilute	BSB-3745-7	$363.00
Presentation: 15 ml Predilute	BSB-3745-15	$639.00
Presentation: .1 ml Concentrate	BSB-3745-01	$211.00
Presentation: .5 ml Concentrate	BSB-3745-05	$458.00
Presentation: 1 ml Concentrate	BSB-3745-1	$727.00
Presentation: Control Slides [5]	BSB-3745-CS	$77.05

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Pygopus 2 (BSB-156), MMab

Intended Use

Summary and Explanation

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