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ROS-1 (EP282), RMab
| SKU: |
BSB 3623 (ASR) |
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Antibody type:
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Rabbit Monoclonal
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Clone:
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EP282
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Isotype:
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IgG
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Concentrate Dilution:
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1:50-1:200
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Localization:
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Cytoplasmic
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Tissue Control:
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Placenta, Lung, SiHa Cells, NSCL ROS1 +
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Species Reactivity:
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Human
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Intended Use
Analyte Specific Reagent
Summary and Explanation
ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) is a receptor tyrosine kinase that undergoes genetic rearrangements in various human cancers and in humans is encoded by the ROS1 gene. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity with structural similarity to the anaplastic lymphoma kinase (ALK) protein. The protein may function as a growth or differentiation factor receptor. ROS1 expression is limited in normal tissues to occasional staining cerebellum, stomach, small intestine, colon and kidney.
Gene rearrangements involving the ROS1 gene were first detected in glioblastoma tumors and cell lines. ROS1 fusion partners include CD74, SLC34A2 and SDC4, leading to oncogenic transformation. ROS1 rearrangement was identified in a cell line derived from a lung adenocarcinoma patient and multiple studies have demonstrated its incidence in lung cancers. While ROS1 is undetectable in the normal lung, studies have described ROS1 rearrangements in 1-2% of NSCLC by FISH. Recent reports have demonstrated strong correlation between ROS1 IHC with FISH positivity. ROS1 fusions have been detected in multiple other tumors, including glioblastoma, non-small cell lung cancer (NSCLC), cholangiocarcinoma, ovarian cancer, gastric adenocarcinoma, colorectal cancer, inflammatory myofibroblastic tumor, angiosarcoma, and epithelioid hemangioendothelioma.
Presentation
ROS-1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: anti-ros-1, anti ros-1, antiros-1, ros1, anti-ros1, anti ros1, antiros1, ROSGC1, Gucy2e, CORD5, CORD6, CYGD, guanylate cyclase 2D membrane retina specific, guanylate cyclase 2D retinal, GUC1A4, GUC2D, LCA, LCA1, RCD2, retGC, RETGC 1, Retinal guanylyl cyclase 1, Rod outer segment membrane guanylate cyclase, ROS GC, ROSGC
Specification Sheets
Safety Data Sheets
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| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 3623 (ASR) | $314.00 |
| Presentation: 7 ml Predilute | BSB 3624 (ASR) | $570.00 |
| Presentation: 15 ml Predilute | BSB 3625 (ASR) | $912.00 |
| Presentation: .1 ml Concentrate | BSB 3626 (ASR) | $223.00 |
| Presentation: .5 ml Concentrate | BSB 3627 (ASR) | $500.00 |
| Presentation: 1 ml Concentrate | BSB 3628 (ASR) | $928.00 |
| Presentation: Control Slides [5] | BSB-9365-CS | $154.00 |
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