S100A9 (EP185), RMab

Summary and Explanation

S100A9, also known as migration inhibitory factor-related protein 14 (MRP-14) or calgranulin- B is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/ or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentation. S100A9 forms a heterodimer, Calprotectin, with S100A8 in a calcium-dependent manner. S100A9 may function in the inhibition of casein kinase.

S100A9 antibody is expressed in granulocytes, monocytes in peripheral blood and in infiltrating macrophages in inflammatory sites, but not in normal tissue macrophages. Elevated plasma levels of S100A9 has been observed in inflammatory disorders such as chronic bronchitis, cystic fibrosis and rheumatoid arthritis. S100A9 antibody is also detected in tumor cells in carcinomas of the liver, lung, breast and thyroid. It is correlated with tumor differentiation.