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Thrombomodulin / CD141 (EP175), RMab
| SKU: |
BSB 2279 |
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Antibody type:
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Rabbit Monoclonal
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Clone:
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EP175
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Isotype:
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IgG
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Concentrate Dilution:
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1:10-1:50
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Localization:
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Membranous, Cytoplasmic
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Tissue Control:
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Placenta, Liver, Kidney, Tonsil, Cervix
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Thrombomodulin, also known as CD141, is an endothelial-specific type 1 membrane receptor that binds thrombin, resulting in the activation of protein C. This causes the degradation of clotting factors Va and VIIIa and reduces the amount of thrombin generated. Defect in Thrombomodulin is a cause of thromboembolic disease, also known as inherited thrombophilia.
Thrombomodulin antibody was initially identified in endothelial cells, but is also found in extra-vascular sites, such as synctiotrophoblasts in the placenta, epithelial tissues in the gingiva, in skin and in the synovial lining cells. In tumors, Thrombomodulin is expressed in vascular tumors and squamous cell carcinoma in a variety of tissues, including oral mucosa, esophagus, and skin. Thrombodulin antibody is a useful marker for detecting angiosarcoma, and can also be used to distinguish between mesothelioma (positive) from lung adenocarcinoma (negative).
Presentation
Thrombomodulin antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: THBD, CD141, CD141 antigen, Fetomodulin, THRM, thrombomodulin, TM, Thrombomodulin precursor, AHUS6, BDCA3, THPH12, thrombomodulin, anti-thrombomodulin, anti thrombomodulin, anti-th, anti th
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| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2279 | $200.00 |
| Presentation: 7 ml Predilute | BSB 2280 | $362.00 |
| Presentation: 15 ml Predilute | BSB 2281 | $653.00 |
| Presentation: .1 ml Concentrate | BSB 2282 | $223.00 |
| Presentation: .5 ml Concentrate | BSB 2283 | $489.00 |
| Presentation: 1 ml Concentrate | BSB 2284 | $746.00 |
| Presentation: Control Slides [5] | BSB 2285 | $77.05 |
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