TRAcP (9C5), MMab

Summary and Explanation

Tartrate-resistant acid phosphatase (TRAcP) is a glycosylated monomeric metallo-enzyme expressed in mammals. It has a molecular weight of approximately 35 kDa, a basic isoelectric point (7.6 – 9.5), and optimal activity in acidic conditions. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. There are also certain pathological conditions whereby expression of TRAcP is increased. These include patients with Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases.

TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts, which also express abundant TRAcP activity.