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CD34 (EP88), RMab
SKU: |
BSB 6485 |
Antibody type:
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Rabbit Monoclonal
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Clone:
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EP88
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Isotype:
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IgG
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Concentrate Dilution:
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1:50-1:200
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Localization:
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Cytoplasmic, Membranous
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Tissue Control:
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Tonsil, Placenta, Appendix
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Species Reactivity:
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Human, Predicted: Mouse, Rat, Sheep, Dog, Pig
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
CD34 functions as a cell-cell adhesion factor and cell-surface glycoprotein. It may also mediate the attachment of stem cells to bone marrow extracellular matrixes or directly to stromal cells. Cells expressing CD34 are normally found in the umbilical cord and bone marrow as hematopoletic cells, and in vascular endothelium. In addition to stem cell recognition, CD34 is expressed by vascular endothelium; it appears that proliferating endothelial cells express this molecule in greater amounts than resting cells. In comparison to factor VIII R Antigen, CD34 stains are stronger and appear to be more sensitive in nature.
In tumors, CD34 antibody expression is found in Alveolar Soft Part Sarcoma, pre B-ALL (positive in 75%), AML(40%), AMLM7 (most), Dermatofibrosarcoma Protuberans, Gastrointestinal Stromal Tumors, Giant Cell Fibroblastoma, Granulocytic Sarcoma, Kaposi’s Sarcoma, Liposarcoma, Malignant Fibrous Histiocytoma, Malignant Peripheral Nerve Sheath tumors, Meningeal Hemangiopericytomas, Meningiomas, Neurofibromas, Schwannomas, and Papillary Thyroid Carcinoma. A negative CD34 may exclude Ewing’s Sarcoma/PNET, Myofibrosarcoma of the breast, and Inflammatory Myofibroblastic tumors of the stomach.
Presentation
CD34 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: CD34, sc74499, sc-74499, 74499, anti-CD34, anti CD34, CD34 stem cell marker, anti-CD34 stem cell marker, anti CD34 stem cell marker, stem cell markers, anti-stem cell markers, anti stem cell markers, CD34 antigen, CD34 molecule, Hematopoietic progenitor cell antigen CD34, AU040960, cluster designation 34, My 10, L selectin ligand, Mucosialin, gp105 120, gp105 120 s, tem cell progenitor progenitor cell, anti-cd34, anti cd34
Specification Sheets
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 6485 | $200.00 |
Presentation: 7 ml Predilute | BSB 6486 | $362.00 |
Presentation: 15 ml Predilute | BSB 6487 | $653.00 |
Presentation: .1 ml Concentrate | BSB 6488 | $223.00 |
Presentation: .5 ml Concentrate | BSB 6489 | $489.00 |
Presentation: 1 ml Concentrate | BSB 6490 | $746.00 |
Presentation: Control Slides [5] | BSB-9087-CS | $77.00 |
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