Claudin-4 (EP417), RMab

Summary and Explanation

Detection of Claudin-4 via IHC allows distinguishing Lung Adenocarcinoma from malignant Mesothelioma in tissue samples. In malignant effusions, Claudin-4 detection effectively identifies Adenocarcinoma from malignant Mesothelioma with high sensitivity and specificity. Another study showed that Claudin-4 detection is an independent positive prognostic factor for Gastric Carcinoma, which restricts the migration of gastric cancer cells. Claudin-4 overexpression in gastric cancer cells is associated with epigenetic derepression and contributes to the suppression of gastric cancer progression and positive prognosis of the patient. On the other hand, Claudin-4 expression is downregulated in epithelial malignancies and in precancerous lesions. In addition, Claudin-4 plays an important role in tumor cell invasion and metastasis. Claudin-4 is a highly specific and sensitive marker to differentiate epithelioid mesotheliomas from metastatic carcinomas.

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Synonyms: claudin 4, claudin-4, CLDN4, claudin4, anti-claudin-4, anti claudin-4, anti-claudin 4