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Claudin-7, claudin 7, cldn7, cldn-7, anti-claudin-7, anti-claudin 7, anti-cldn7, anti-cldn-7 MAIN

Claudin-7 (EP399), RMab

Presentation:

Price: $196.00

SKU:	BSB-3719-3
Antibody type:	Rabbit Monoclonal
Clone:	EP399
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic, Membranous, Nuclear
Tissue Control:	Breast, Colon, Fallopian Tubem Pancreas
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Claudin-7 is encoded by the CLDN7 gene and is a member of the claudin family. Claudin-7 is a component of tight junctions and plays important roles in maintaining cell polarity and tightly connecting the barriers between cells. Abnormal Claudin-7 protein expression is closely related to tumor occurrence, development, and metastasis. Claudin-7 expression is down-regulated in Colorectal Cancer (CRC) and Lung Cancer tissues and loss of Claudin-7 is associated with the degree of cancer cell differentiation and metastasis.

Claudin-7 may serve as a tumor suppressor, as it is involved in pathways of cell proliferation and epithelial barrier formation through Integrin signaling networks. The deficient extracellular matrix in cells with low Claudin-7 antibody expression promotes abnormal growth patterns and metastasis in Ductal and Lobular Breast Carcinomas, and Claudin-7 expression is lost in ~50% of primary tumors in Breast Cancers. While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.

Synonyms: claudin-7, claudin 7, cldn7, cldn-7, anti-claudin-7, anti-claudin 7, anti-cldn7, anti-cldn-7

Specification Sheets

IVD

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3719-3	$196.00
Presentation: 7 ml Predilute	BSB-3719-7	$350.00
Presentation: 15 ml Predilute	BSB-3719-15	$616.00
Presentation: .1 ml Concentrate	BSB-3719-01	$203.00
Presentation: .5 ml Concentrate	BSB-3719-05	$441.00
Presentation: 1 ml Concentrate	BSB-3719-1	$700.00
Presentation: Control Slides [5]	BSB-3719-CS	$63.00

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Claudin-7 (EP399), RMab

Intended Use

Summary and Explanation

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