Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Immunoglobulin A (IgA) is the main immunoglobulin inmucous secretions, including tears, saliva, and colostrum,as well as respiratory, intestinal, prostatic, and vaginal secretions. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes,secretory IgA provides protection against microbes proliferating in body secretions, especially those of the digestive and respiratory tracts.
IgA antibody reacts with surface immunoglobulin IgA alpha chains. It is extremely useful when identifying Acute Leukemias, IgA Myelomas, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. However, due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies. Lupus nephritis isan inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q.
Presentation
The IgA/FITC is a purified rabbit polyclonal antibody labeled with FITC diluted in a Tris Buffered Saline solution (pH 7.2) containing stabilizing proteins and preserved with sodiumazide. It is provided in liquid form.
