For In Vitro Diagnostic Use
Lambda detects surface immunoglobulin on normal and neoplastic B-cells. Lambda staining is seen in B-cell follicles of human lymphoid tissue.
When studying B-cell neoplasms, the determination of light chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either kappa or lambda light chains, where as reactive proliferations display a mixture of kappa and lambda-positive cells. If only a single light-chain type is detected, a lympho proliferative disorder is very likely. Monoclonality is determined by a kappa-lambda ratio greater than or equal to 3:1, a lambda-kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population. In IgG-dominant immune complex-mediated glomerulonephritis, there are multiple pathological findings that strongly suggest the diagnosis of Lupus Nephritis including immunofluorescence staining for IgG, IgM, IgA, Kappa or Lambda, C3 and C1.
The Lambda/FITC is a purified rabbit polyclonal antibody labeled with FITC diluted in a Tris Buffered Saline solution (pH 7.2) containing stabilizing proteins and preserved with sodium azide. It is provided in liquid form.
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