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MCM2 (RBT-MCM2), RMab
SKU: |
BSB 6331 |
Antibody type:
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Rabbit Monoclonal
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Clone:
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RBT-MCM2
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Isotype:
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IgG
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Concentrate Dilution:
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1:100-1:500
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Localization:
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Nuclear
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Tissue Control:
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HSIL, Cervical, Breast Cancer
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
MCM-2 (mini-chromosome maintenance 2) is a human gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex, and may be involved in the formation of replication forks and in the recruitment of other DNA replication-related proteins. This protein forms a complex with MCM-4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by protein kinases CDC2 and CDC7.
MCM-2 is essential for eukaryotic DNA replication and drives the formation of pre-replicative complexes, which is the key first step during the G1 phase. Therefore, altered MCM-2 antibody expression may be a hallmark of cell-cycle deregulation, which could be the most essential mechanism in the development and progression of human cancers. MCM2 has been identified by DNA microarray and transcriptional profiling as a gene that is over-expressed in Cervical Carcinomas. This protein is over-expressed in Cervical Dysplasia as a result of HPV infection. The over-expression of MCM-2 provides the link between oncogenic HPV infection and the molecular event of Cervical Dysplasia.
Presentation
MCM2 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: anti-MCM2, anti MCM2, anti-mcm-2, anti mcm-2, anti-mcm 2, anti mcm 2, BM28, CCNL1, cdc19, CDCL1, cell devision cycle like 1, cyclin like 1, D3S3194, DNA replication licensing factor MCM2, KIAA0030, MCM2 minichromosome maintenance deficient 2 mitotin, MGC10606, minichromosome maintenance complex component 2, minichromosome maintenance deficient 2 mitotin, minichromosome maintenance protein 2 homolog, MITOTIN, Nuclear protein BM28
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 6331 | $279.30 |
Presentation: 7 ml Predilute | BSB 6332 | $507.15 |
Presentation: 15 ml Predilute | BSB 6333 | $811.65 |
Presentation: .1 ml Concentrate | BSB 6334 | $198.45 |
Presentation: .5 ml Concentrate | BSB 6335 | $444.15 |
Presentation: 1 ml Concentrate | BSB 6336 | $825.30 |
Presentation: Control Slides [5] | BSB 6337 | $67.00 |
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