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p21 (DCS-60.2), MMab

Presentation:

Price: $130.00

SKU:	BSB 2063
Antibody type:	Mouse Monoclonal
Clone:	DCS-60.2
Isotype:	IgG2a
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic, Nuclear
Tissue Control:	Tonsil, Colon, Fallopian Tube, Breast Cancer
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

p21 is a potent cyclin-dependent kinase inhibitor. The p21 protein binds to and inhibits the activity of cyclin-CDK2 or -CDK1 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a varity of stimuli. In addition to growth arrest, p21 can mediate cellular senescence. p21 can also interact with proliferating cell nuclear antigen (PCNA) and plays a regulatory role in S phase DNA replication and DNA damage repair.

Normal cells typically display a rather intense nuclear p21 antibody expression. Loss of p21 expression has been associated with poor prognosis in several carcinomas including Gastric Carcinoma, Non-Small Cell Lung Carcinoma and Thyroid Carcinoma.

Presentation

p21 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: Cdkn1a, CIP1, Waf1, anti-p21, anti p21, anti CDKN1A, anti CIP1, anti WAF1, anti-CDKN1A, anti-CIP1, anti-WAF1, CAP20, CDKI, Cdkn1, cyclin dependent kinase inhibitor 1, cyclin dependent kinase inhibitor 1A P21, mda6, Melanoma differentiation associated protein, P21, p21 WAF1 CIP1, p21Cip1, p21WAF, SDI1

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 2063	$130.00
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Presentation: 15 ml Predilute	BSB 2065	$440.00
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Presentation: .5 ml Concentrate	BSB 2067	$344.00
Presentation: 1 ml Concentrate	BSB 2068	$529.00
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